What is the first step in DNA replication?

• A. Synthesis of RNA primers by primase
• B. Unwinding of the DNA double helix by helicase
• C. Binding of DNA polymerase to the template strand
• D. Joining of Okazaki fragments by DNA ligase

Answer: (B)

Verified step by step guidance

1. Understand that DNA replication is a complex process involving multiple steps and enzymes.
2. Recognize that the first step in DNA replication is the unwinding of the DNA double helix.
3. Identify the enzyme responsible for this unwinding process, which is helicase.
4. Helicase breaks the hydrogen bonds between the complementary bases, separating the two strands of DNA.
5. This separation creates a replication fork, allowing other enzymes to access the single-stranded DNA for further replication processes.