Textbook Question
What aspect of DNA structure makes it possible for the proteins of nucleotide excision repair to recognize many different types of DNA damage?
(a) the polarity of each DNA strand
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14. DNA Synthesis
DNA Repair
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Which of the following DNA sequences would be the most likely to be damaged by UV radiation?
A
TTCGGA
B
GCGCGC
C
TTAGGC
D
TTTTAA
Verified step by step guidance1
Understand that UV radiation primarily causes damage to DNA by forming thymine dimers, which occur when two adjacent thymine bases bond together.
Identify the sequences provided: 'TTCGGA', 'GCGCGC', 'TTAGGC', and 'TTTTAA'.
Look for sequences with adjacent thymine bases, as these are more susceptible to forming thymine dimers.
Analyze each sequence: 'TTCGGA' has two adjacent thymines, 'GCGCGC' has no thymines, 'TTAGGC' has two adjacent thymines, and 'TTTTAA' has four adjacent thymines.
Conclude that the sequence 'TTTTAA' is most likely to be damaged by UV radiation due to the presence of multiple adjacent thymine bases, increasing the likelihood of dimer formation.
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