Which of the following would increase the release of oxygen from red blood cells?

• A. A decrease in pH and an increase in the P_O2
• B. An increase in pH and an increase in the P_O2
• C. An increase in pH and a decrease in the P_O2
• D. None of the listed responses is correct.
• E. A decrease in pH and a decrease in the P_O2

Answer: (E)

Verified step by step guidance

1. Understand the Bohr effect: The Bohr effect describes how changes in pH and carbon dioxide concentration affect the affinity of hemoglobin for oxygen. A decrease in pH (more acidic environment) reduces hemoglobin's affinity for oxygen, promoting oxygen release.
2. Consider the role of partial pressure of oxygen (PO2): A decrease in PO2 means there is less oxygen available in the surrounding environment, which encourages hemoglobin to release more oxygen to tissues.
3. Analyze the options: The correct scenario for increased oxygen release involves both a decrease in pH and a decrease in PO2, as these conditions together enhance the release of oxygen from hemoglobin.
4. Evaluate the given options: Compare each option to the conditions that promote oxygen release. Only the option with both a decrease in pH and a decrease in PO2 matches the conditions described by the Bohr effect.
5. Conclude with the correct choice: Based on the analysis, the correct answer is the option that states a decrease in pH and a decrease in PO2, as these conditions align with the physiological mechanisms that increase oxygen release from red blood cells.