During which phase of mitosis do the sister chromatids separate?

• A. Telophase
• B. Anaphase
• C. Prophase
• D. Metaphase

Answer: (B)

Verified step by step guidance

1. Understand the process of mitosis, which is the division of a single cell into two genetically identical daughter cells. Mitosis consists of several phases: prophase, metaphase, anaphase, and telophase.
2. Recall that sister chromatids are identical copies of a chromosome connected by a centromere. During mitosis, these chromatids need to be separated to ensure each daughter cell receives an identical set of chromosomes.
3. Review the phases of mitosis: In prophase, chromosomes condense and become visible. In metaphase, chromosomes align at the cell's equatorial plane. In anaphase, sister chromatids are pulled apart toward opposite poles of the cell. In telophase, the cell prepares to divide into two daughter cells.
4. Focus on anaphase: This is the phase where the sister chromatids are separated. The centromeres split, and the chromatids are pulled by spindle fibers toward opposite ends of the cell.
5. Conclude that the separation of sister chromatids is a key event in anaphase, ensuring that each new cell will have the correct number of chromosomes.