Which of the following will NOT cause hyperglycemia?

• A. Decreased insulin sensitivity
• B. Excessive glucagon release
• C. Increased insulin secretion
• D. Uncontrolled gluconeogenesis

Answer: (C)

Verified step by step guidance

1. Step 1: Understand the concept of hyperglycemia. Hyperglycemia refers to elevated blood glucose levels, which can occur due to various factors affecting glucose metabolism, insulin function, or hormone regulation.
2. Step 2: Analyze the role of insulin in blood glucose regulation. Insulin is a hormone that lowers blood glucose levels by promoting glucose uptake into cells and inhibiting gluconeogenesis (the production of glucose from non-carbohydrate sources). Increased insulin secretion typically reduces blood glucose levels, preventing hyperglycemia.
3. Step 3: Examine the impact of decreased insulin sensitivity. Decreased insulin sensitivity, also known as insulin resistance, means that cells do not respond effectively to insulin, leading to higher blood glucose levels and potentially causing hyperglycemia.
4. Step 4: Evaluate the effect of excessive glucagon release. Glucagon is a hormone that raises blood glucose levels by stimulating glycogen breakdown and gluconeogenesis. Excessive glucagon release can contribute to hyperglycemia.
5. Step 5: Consider the role of uncontrolled gluconeogenesis. Uncontrolled gluconeogenesis leads to excessive production of glucose, which can elevate blood glucose levels and cause hyperglycemia. Therefore, increased insulin secretion is the only option that does NOT cause hyperglycemia.