Which of the following types of lung cancer is most strongly associated with smoking and typically originates in the central bronchi, often presenting with keratin pearls and intercellular bridges?

• A. Adenocarcinoma
• B. Small cell carcinoma
• C. Squamous cell carcinoma
• D. Large cell carcinoma

Answer: (C)

Verified step by step guidance

1. Understand the question: The problem asks about a type of lung cancer strongly associated with smoking, originating in the central bronchi, and presenting with specific histological features such as keratin pearls and intercellular bridges.
2. Review the histological features: Keratin pearls and intercellular bridges are hallmark characteristics of squamous cell carcinoma, which is a type of epithelial cancer.
3. Connect smoking to lung cancer types: Smoking is most strongly associated with squamous cell carcinoma and small cell carcinoma. However, squamous cell carcinoma is specifically known for its central bronchi origin and histological features.
4. Differentiate between the options: Adenocarcinoma typically originates in the peripheral lung tissue and is less associated with smoking. Small cell carcinoma is strongly linked to smoking but does not present with keratin pearls or intercellular bridges. Large cell carcinoma is a less specific diagnosis and lacks the described histological features.
5. Conclude based on evidence: Squamous cell carcinoma matches all the criteria provided in the question, including its association with smoking, central bronchi origin, and histological features.