A single base substitution is LEAST likely to be deleterious (dangerous) when the change results in _____.

• A. Replacement of a codon specifying a hydrophilic amino acid with a codon that specifies a hydrophobic amino acid.
• B. Replacement of a codon which codes for an amino acid with a stop codon.
• C. The change of a codon specifying a specific amino acid important for the active site of the protein.
• D. Replacement of a codon specifying an amino acid with a redundant codon specifying the same amino acid.