Which of the following is NOT true regarding the differences of transcription in eukaryotes and prokaryotes?

Eukaryotes use multiple transcription factors to help initiate transcription.

Most eukaryotes have regulatory sites that are close to their promoters.

Most prokaryotes transcribe multiple genes under the regulation of a single operon.

Prokaryotic transcription factors usually interact directly with RNA polymerase while eukaryotic transcription factors do not.