Which of the following statements is true?

• A. The cytoskeleton inhibits cell migration.
• B. The extracellular matrix is not involved in the migration of cells.
• C. Cell adhesion molecules are secreted glycoproteins found in the extracellular matrix.
• D. Cell adhesion molecules are located inside cells.
• E. Cells reach specific destinations through the action of cell adhesion molecules and the extracellular matrix.

Answer: (E)

Verified step by step guidance

1. Understand the role of the cytoskeleton: The cytoskeleton is a network of fibers within cells that provides structural support and plays a role in cell movement, not inhibition of migration.
2. Examine the extracellular matrix (ECM): The ECM is a complex network of proteins and carbohydrates outside cells that provides structural support and influences cell behavior, including migration.
3. Identify the function of cell adhesion molecules (CAMs): CAMs are proteins located on the cell surface that help cells stick to each other and to the ECM, facilitating cell movement and positioning.
4. Clarify the location of CAMs: CAMs are not secreted into the ECM; they are typically found on the cell surface, where they interact with the ECM and other cells.
5. Synthesize the information: Cells reach specific destinations through the coordinated action of CAMs and the ECM, which guide and support cell migration.