Which step occurs in the A site of the ribosome during translation?

• A. Release of the polypeptide chain
• B. Translocation of tRNA
• C. Binding of aminoacyl-tRNA
• D. Formation of peptide bonds

Answer: (C)

Verified step by step guidance

1. Understand the structure and function of the ribosome during translation. The ribosome has three sites: A (aminoacyl), P (peptidyl), and E (exit). Each site plays a specific role in the process of translation.
2. Recognize the role of the A site in the ribosome. The A site is where the aminoacyl-tRNA binds to the ribosome. This tRNA carries the next amino acid to be added to the growing polypeptide chain.
3. Identify the process of binding of aminoacyl-tRNA. During translation, the aminoacyl-tRNA enters the A site, matching its anticodon with the codon on the mRNA strand, ensuring the correct amino acid is added.
4. Differentiate between the steps occurring at the A site and other sites. The P site is where peptide bond formation occurs, and the E site is where tRNA exits the ribosome after its amino acid has been added to the chain.
5. Conclude that the binding of aminoacyl-tRNA is the step that occurs in the A site of the ribosome during translation, as it is crucial for the continuation of protein synthesis.