16. Regulation of Expression

The Trp Operon

trp Operon & Attenuation explained in under 15 minutes

In the Presence of Tryptophan

The trp operon will be continuously expressed.

The trp operon will be expressed in the presence of tryptophan only.

The trp operon will be expressed in the absence of tryptophan only.

There will be no effect on the trp operon.

If the trp regulatory gene mutates so that the repressor protein can no longer bind to tryptophan what will be the result?

 No. It may have a role in inducing sleep in humans, but that is not its basic function. 

 It is an important constituent of cell walls in both humans and bacteria. 

 No. It is not particularly used in cell walls, and humans don't have cell walls. 

 No. Allolactose induces the lac operon. 

 It is an important enzyme in the glycolysis pathway. 

 No. It is one of the 20 amino acids used to synthesize proteins. 

 It is one of the 20 amino acids used by all organisms to synthesize proteins. 

The pathway that synthesizes tryptophan is an anabolic pathway.

This chapter contains a lengthy discussion of the trp operon involved in regulating the synthesis of tryptophan. In the case of E. coli, the bacterium may need to synthesize tryptophan, or its host, a human, may supply all the tryptophan it needs. Why do both bacteria and humans need tryptophan?

trp Operon | Tryptophan Operon

trp operon

Thinking Through the trp Operon

The trp&nbsp;operon consists of ________ genes that encode tryptophan biosynthesis enzymes.

Tryptophan Operon

Yes, this is why tryptophan is the co-repressor of the trp operon.

No, this is why tryptophan is the inducer of the trp operon.

Yes, this is why tryptophan is the repressor of the trp operon.

Based on the information you know about the trp operon, is the creation of tryptophan expensive to the cell?

Trp Operon

The inducer cannot bind to the operator, so trp operon transcription occurs.

The active repressor cannot bind to the operator, so trp operon transcription is reduced.

The inactive repressor cannot bind to the operator, so trp operon transcription occurs.

The repressor binds to the corepressor, and trp operon transcription occurs.

The active repressor binds to the operator, so trp operon transcription is repressed.

In the absence of tryptophan, ______:

If a particular operon encodes enzymes for making an essential amino acid and is regulated like the trp operon, then
a. the amino acid inactivates the repressor.
b. the repressor is active in the absence of the amino acid.
c. the amino acid acts as a corepressor.
d. the amino acid turns on transcription of the operon.

In the Absence of Tryptophan

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Review of the Lac Operon & Trp Operon

Eukaryotic Transcriptional Control

Glucose's Impact on Lac Operon

Prokaryotic Gene Regulation via Operons

Introduction to Eukaryotic Gene Regulation

Eukaryotic Post-Translational Regulation

Eukaryotic Post-Transcriptional Regulation

The Lac Operon

Eukaryotic Chromatin Modifications

Introduction to Regulation of Gene Expression

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