Which of the following cell types does not express MHC Class II molecules on its surface?

• A. Dendritic cells
• B. Neutrophils
• C. Macrophages
• D. B cells

Answer: (B)

Verified step by step guidance

1. Understand the role of MHC Class II molecules: MHC Class II molecules are proteins found on the surface of certain immune cells. They present antigens to helper T cells, which is crucial for initiating an immune response.
2. Identify the cell types that typically express MHC Class II molecules: These include professional antigen-presenting cells such as dendritic cells, macrophages, and B cells. These cells are involved in the adaptive immune response.
3. Consider the function of neutrophils: Neutrophils are a type of white blood cell that primarily engage in phagocytosis and are part of the innate immune system. They are not typically involved in antigen presentation to T cells.
4. Recognize that neutrophils do not express MHC Class II molecules: Unlike dendritic cells, macrophages, and B cells, neutrophils do not present antigens to helper T cells and therefore do not express MHC Class II molecules on their surface.
5. Conclude that among the given options, neutrophils are the cell type that does not express MHC Class II molecules, aligning with their role in the innate immune response rather than the adaptive immune response.