Which of the following is not a sign of inflammation?

• A. Swelling
• B. Redness
• C. Pain
• D. Fever

Answer: (D)

Verified step by step guidance

1. Understand the concept of inflammation: Inflammation is a biological response to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective response involving immune cells, blood vessels, and molecular mediators.
2. Identify the classic signs of inflammation: The classic signs of inflammation are redness (rubor), heat (calor), swelling (tumor), pain (dolor), and loss of function (functio laesa). These signs are due to the increased blood flow and immune activity in the affected area.
3. Analyze the options given: Swelling, redness, and pain are all classic signs of inflammation. Fever, however, is not one of the classic signs of inflammation. Fever is a systemic response and can occur due to inflammation, but it is not a localized sign.
4. Clarify the role of fever: Fever is an increase in body temperature that often accompanies inflammation, but it is considered a systemic response rather than a localized sign. It is caused by pyrogens that affect the hypothalamus, leading to an increase in body temperature.
5. Conclude which option is not a sign of inflammation: Based on the analysis, fever is not a classic sign of inflammation, whereas swelling, redness, and pain are. Therefore, fever is the correct answer to the question.