What does the M checkpoint in the cell cycle check for?

• A. Sufficient cell size and nutrients
• B. Completion of DNA replication
• C. Presence of growth factors
• D. Proper attachment of chromosomes to the spindle apparatus

Answer: (D)

Verified step by step guidance

1. Understand the cell cycle: The cell cycle consists of several phases, including G1, S, G2, and M. Each phase has specific checkpoints to ensure the cell is ready to proceed to the next stage.
2. Identify the M phase: The M phase, or mitosis, is where the cell divides its chromosomes into two sets, leading to cell division.
3. Learn about the M checkpoint: The M checkpoint, also known as the spindle checkpoint, occurs during mitosis. It ensures that all chromosomes are properly attached to the spindle apparatus before the cell proceeds with division.
4. Explore the function of the spindle apparatus: The spindle apparatus is responsible for separating chromosomes during cell division. Proper attachment ensures that each daughter cell receives the correct number of chromosomes.
5. Recognize the importance of the M checkpoint: This checkpoint prevents errors in chromosome separation, which could lead to aneuploidy or other genetic abnormalities in the daughter cells.