Antibody class switching rearranges the genes within a B cell which controls the type of antibody secreted by the plasma B cell. During this gene rearrangement, the ______ region of the antibody is affected and the ______ region of the antibody is unaffected. This means that antibody class switching is antigen specificity ______.

• A. Constant region; Variable region; Independent.
• B. Variable region; Constant region; Independent.
• C. Constant region; Variable region; Dependent.
• D. Variable region; Constant region; Dependent.