Which of the following statements about replication origins is/are correct?

• A. Bacterial chromosomes have a single origin of replication, but eukaryotic chromosomes have many origins.
• B. The DNA sequence at the origin of replication is recognized by specific proteins that bind to the origin.
• C. The two strands of DNA at the origin of replication are separated, creating a replication bubble.
• D. Replication proceeds in both directions from each origin.
• E. All of the listed responses are correct.