Which of the following statements about the active site of an enzyme is correct?

• A. The active site has a fixed structure (shape).
• B. Coenzymes are rarely found in the active site of an enzyme.
• C. The structure of the active site is not affected by changes in temperature.
• D. The active site allows the reaction to occur under the same environmental conditions as the reaction without the enzyme.
• E. The active site may resemble a groove or pocket in the surface of a protein into which the substrate fits.