Which of the following statements about enzymes is/are true?

• A. Enzymes increase the rate of a reaction by raising the activation energy for reactions.
• B. Enzymes react with their substrate (form chemical bonds), forming an enzyme-substrate complex, which irreversibly alters the enzyme.
• C. The more heat that is added to a reaction, the faster the enzymes will function.
• D. All of the listed responses are correct.
• E. Enzymes speed up the rate of the reaction without changing the DG for the reaction.