Which statement about the sidedness of the plasma membrane is correct?

• A. Parts of proteins that are exposed on the cytoplasmic side of the endoplasmic reticulum are also exposed on the cytoplasmic side of the plasma membrane.
• B. The asymmetrical distribution of membrane proteins, lipids, and carbohydrates across the plasma membrane is determined as the membrane is being constructed.
• C. Every integral membrane protein has a specific orientation in the plasma membrane.
• D. The two lipid layers may differ in specific lipid composition.
• E. All of the listed responses are correct.