Which of the following determines the sign of ΔG for a reaction?

• A. The enzyme catalyzing the reaction's having a high affinity (strength of binding) for the reactants
• B. The enzyme catalyzing the reaction's having a low affinity for the products
• C. The free energy of the products
• D. The free energy of the reactants
• E. The free energy of the reactants and the free energy of the products