Because of their structure, lipid-soluble hormones bind to the receptors of target cells ______.

• A. within the extracellular matrix
• B. inside the cytoplasm or nucleus
• C. on the outer surface of the plasma membrane
• D. in the lysosomes

Answer: (B)

Verified step by step guidance

1. Understand the nature of lipid-soluble hormones: Lipid-soluble hormones, such as steroid hormones, are hydrophobic and can easily pass through the lipid bilayer of the plasma membrane due to their nonpolar structure.
2. Recognize the location of receptors for lipid-soluble hormones: Unlike water-soluble hormones, which bind to receptors on the outer surface of the plasma membrane, lipid-soluble hormones bind to receptors located inside the cell, either in the cytoplasm or the nucleus.
3. Clarify the mechanism of action: Once inside the cell, lipid-soluble hormones bind to their specific intracellular receptors, forming a hormone-receptor complex. This complex can then directly interact with DNA to regulate gene expression.
4. Eliminate incorrect options: The extracellular matrix, outer surface of the plasma membrane, and lysosomes are not locations where lipid-soluble hormones bind to receptors. These are associated with other types of molecules or processes.
5. Conclude the correct answer: Based on the structure and mechanism of lipid-soluble hormones, their receptors are located inside the cytoplasm or nucleus of the target cells.