Biochemistry

Learn the toughest concepts covered in Biochemistry with step-by-step video tutorials and practice problems by world-class tutors

12. Biosignaling

Inhibitory Adenylate Cyclase GPCR Signaling

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1

concept

Inhibitory Adenylate Cyclase GPCR Signaling

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Problem

The addition of the nonhydrolyzable GTP-analog, GTPγS (shown below), is a common cell culture technique. If only affecting the inhibitory pathway, what effect would GTPγS have on cellular cAMP levels?

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Problem

If a chemical is an inhibitor of the enzyme adenylyl cyclase, which of the following steps in the GPCR signaling pathway would be directly blocked?

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concept

Inhibitory Adenylate Cyclase GPCR Signaling

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example

Inhibitory Adenylate Cyclase GPCR Signaling Example 1

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Problem

How does GPCR termination differ from GPCR desensitization?

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Problem

Which of the following statements about beta-arrestin and GPCRs is TRUE?

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Problem

Which of the following are involved in the desensitization of the β-adrenergic receptor?