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Biochemistry
Learn the toughest concepts covered in Biochemistry with step-by-step video tutorials and practice problems by world-class tutors
8. Protein Function
Chymotrypsin
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1
concept
Chymotrypsin
4m
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2
concept
Chymotrypsin
5m
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3
Problem
Which amino acids in chymotrypsin’s active site are critical participants in the cleavage of the substrate?
A
His, Ser, Asn.
B
His, Ser, Asp.
C
His, Ser.
D
Asp, Lys.
4
Problem
The following polypeptide N-G-I-F-D-A-Y-G-N-T-W-R-A-P-C-F-V-A is cleaved by chymotrypsin to produce multiple peptide fragments. Based on the specificity of chymotrypsin cleavage, how many peptide fragments are produced?
A
2 peptide fragments.
B
3 peptides fragments.
C
4 peptide fragments.
D
5 peptide fragments.
E
6 peptide fragments.
F
No cleavage event occurs
5
Problem
The activity of chymotrypsin drastically changes as the pH fluctuates in the relatively small range of pH 5-9. What amino acid residue in chymotrypsin’s active site is most likely to be responsible for this effect of pH?
A
Asp-102.
B
His-157.
C
Ser-195.
D
Tyr-23.
E
Cys-198.
F
Asn-122.