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Biochemistry
Learn the toughest concepts covered in Biochemistry with step-by-step video tutorials and practice problems by world-class tutors
4. Protein Structure
Chaperone Proteins
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concept
Chaperone Proteins
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2
Problem
Heat shock protein 70 (HSP70), a chaperone protein found in many organisms, is one of the most highly conserved proteins in all of biology. Which of the following statements about HSP70 is true?
A
HSP70 operates by forming a large cage around the unfolded polypeptide to increase its solubility.
B
HSP70 facilitates proper protein folding without the use of energy.
C
Cellular expression of HSP70 concentration significantly increases in high temperature environments.
D
Expression of HSP70 concentration decreases or stays constant in high temperature environments.
3
Problem
Which statement best describes how chaperones perform their function?
A
They prevent intermolecular hydrophobic interactions to facilitate proper protein folding.
B
They prevent the premature aggregation of secondary structures, allowing the hydrophobic core to form.
C
Chaperones are proteases that digest and disrupt protein aggregates when they form.
D
They hydrolyze ATP to physically manipulate proteins into their appropriate shape.
4
Problem
Which statement most accurately characterizes the effect of high temperatures (>50˚C) on protein folding?
A
High temperatures increase the rate of protein folding so proteins adopt their native fold faster.
B
There is little to no effect of high temperature on protein folding.
C
At high temperatures, proteins are denatured but will re-fold into their native state upon cooling.
D
At high temperatures, proteins are denatured and at risk of forming intermolecular aggregates.
5
Problem
Which of the following statements is false concerning Heat shock protein 60 (HSP60), a chaperonin protein.
A
HSP60 is required for some proteins to make their proper protein folding process spontaneous.
B
Like HSP70, HSP60 facilitates proper protein folding through binding & hydrolysis of ATP.
C
Cellular expression of HSP60 concentration increases in high temperature environments.
D
HSP60 operates by forming a large cage that the unfolded polypeptide enters to assume its native fold.