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Biochemistry

Learn the toughest concepts covered in Biochemistry with step-by-step video tutorials and practice problems by world-class tutors

7. Enzyme Inhibition and Regulation

Allosteric Regulation

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Allosteric Regulation

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So now that we've covered enzyme kinetics in this video, we're going to introduce yet another way that cells can regulate their reactions. And that is, through Alice Terek Regulation. Now recall from your previous biology courses that a metabolic pathway is just a Siris of chemical reactions that is related to some critical biological process. For instance, glide calluses, which I'm sure most of you have already covered in your previous biology courses. But later in this course, we're going to cover glide calluses and ah lot mawr detail. But for now, let's focus on metabolic pathways. And if we take a look at our image down below notice, we're showing you a metabolic pathway. And each of these letters that we see down below represents a different reaction component. And each of these arrows that we see represents a different reaction. And so you can see this is exactly what we mean by a metabolic pathways, just a Siris of all of these chemical reactions, and notice that each of these chemical reactions is being catalyzed by an enzyme. And so most of the enzymes in the metabolic pathway are going to follow the MK Ellis meant in kinetics that we've already covered in our previous lesson videos, which is fantastic. However, most metabolic pathways also have at least one enzyme that has an even greater effect on the kinetics of all of these reactions, even more so than enzymes that display meticulous meant and kinetics. And these enzymes are specifically referred to as Allah stare IQ enzymes. And that's because they display Alistair Kinetics and are regulated Alistair Erik Lee as we'll talk more about moving forward in our course. But if we take a look down below at our metabolic pathway again, notice that most of these reactions here are being catalyzed by enzymes that display McKay list meant in kinetics, and that would be all of these red enzymes enzymes 234 and five. But notice that again at every metabolic pathway has at least one enzyme that has an even greater effect on the kinetics. And that would be enzyme number one here, which is going to display Allah's Starik kinetics and therefore makes enzyme number one and Alistair Eric Enzyme. And so again, this enzyme right here is going to essentially control the kinetics of this entire metabolic pathway. More so than enzymes that display McHale is meant and kinetics. And so, as we move forward in our course, we're going to talk. Maura, Maura about thes Alice, Terek Enzymes and Alice Derek Kinetics, as well as Alice Derek Regulation. So I'll see you guys in our next video.
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Allosteric Regulation

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So from our last lesson video, we know that pretty much every metabolic pathway has at least one enzyme known as an Alice Terek enzyme that has a great effect on the kinetics or the speed of the entire metabolic pathway. And so what exactly are these Alice Terek Enzymes? Well, these Alice Terek enzymes are highly complex and highly regulated enzymes that monitor the flow of biochemicals in metabolic pathways. And so these Alice Derek Enzymes are much mawr complex and much more highly regulated than the meticulous mention enzymes that we've covered in our previous lesson videos. And so that's what makes these Alice Derek enzymes perfect candidates for catalyzing and controlling key steps in metabolic pathways to control the kinetics or the speed of these metabolic pathways. And so notice down below and our image we're showing you this blue structure here, which is a representation of the Alice Terek enzyme. And so what's important to know about these Alice Derek Enzymes is that they usually have multiple poly peptide chains, which means that these Alice Derek Enzymes display quaternary protein structure and so notice that within this blue structure here we have these four blue circles and each of these blue circles here represents a different poly peptide chain. And so, uh, this is much different than the McHale is meant in enzymes, which usually only have one poly peptide chain. Now, notice also that each of these poly peptide chains that come together to make our Alice Terek enzyme they each have their own active site. And so notice over here, what we have is the active site getting pointed to, which is this circular shape. And this is going of course, the out theatrics site is what fits the substrate. And so again, notice Each poly peptide chain has its own active site but also noticed that each poly peptide chain also has its own al oh stare IQ site. And so the Alice Terek site is specifically for Alice Terek affect er's. And so the reason that Alice Derek Enzymes are called Alice Derek Enzymes is because they are regulated by these Alice Derek Affect er's. And so what exactly are these Alice Derek defectors? Well, Alice Derek defectors are just small molecules that will bind to Alice Derek sites on the enzyme to regulate its activity. And so recall that Alice Derek sites are just alternative sites on the enzyme other than the active site. And so that's exactly what we're seeing up above these square, uh, shapes. Here are the positions of the Alice Derek sites, where the Alice Derek Effect er combined to regulate the activity of this entire Alice Derek enzyme. And so, as we move forward in our course, we're going to talk about all of the different types of Alistair Icka factors. But for now, this here concludes our introduction to Alice Derek Enzymes and a sui move forward. We'll talk mawr about how these Alice Derek Enzymes display Alistair Kinetic. So I'll see you guys in our next video.
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