Motor Proteins

in this video, we're going to begin our discussion on motor proteins so motor proteins actually create movement using the sido skeleton. And so before we talk any more details about motor proteins, let's first do a quick recap on the side of skeleton. So recall from way back in our previous lesson videos that the sido skeleton consists of micro filaments, intermediate filaments and micro tubules, and so down below in the depiction of ourselves here you can see we've got the cell membrane and inside of ourselves you can see a lot of different structures, including the different structures of the site of skeleton. So you can see that we have micro filaments. We've got intermediate filaments and we've got micro tubules all within ourself. And really, what the's sido skeleton components function to do is, uh, they function to provide cell shape so you can see that here you can see the distribution of the site a skeleton in ourselves so they do provide cell shape. They also help to provide movement of cells, and they can also provide transportation of molecules within the cell. And they could be involved in signaling as well because they can respond to external molecules, and that can cause, uh, the site of skeleton to shift inside. And so this is going to be important. Thio. Remember the different components of sight of skeletons because different motor proteins will interact with different parts of the site of skeleton. And so, in our next lesson video, we'll be able to talk Maura about these motor proteins, so I'll see you guys in that video.

So now that we've briefly covered the site of skeleton, we can focus more on motor proteins, and so motor proteins are going to be proteins themselves that use energy in the form of ATP. And they use the site a skeleton as tracks in order to create molecular movement. Now this molecular movement is responsible for muscle contractions, which we'll talk a lot more about later in our course. They're also responsible for movements of individual cells through their environments. And they're responsible for intracellular movement as well, in terms of transportation of molecules and organelles within the cell, and will also be able to talk more about this idea as we move forward in our courts. Now, there are actually many different types of motor protein, so we can't cover them all in this course. But some of them or well characterized motor proteins that your professors might expect you guys to know our Miocene, Kennison and dining. And so we've got the structures of these three motor proteins down below, so the first one right here is Mirelson. The next one that we have here is Kinison, and then last but not least over here on the far right. We have dining. And so, as we move forward in our course, will be able to talk Maura about each of these three different motor proteins. But I can tell you now that these three motor proteins are gonna interact with different components of the site. Oh, skeleton myson is gonna interact with micro filaments, whereas Kennison and dining are gonna interact with micro tubules. And again we'll be able to talk more about that as we move forward in our course, starting with my Yasin. So I'll see you guys in our next video.

in this video, we're going to talk more about the motor protein Miocene. So myson is specifically a motor protein that is going to move along. Thin acting micro filaments. And so myson is responsible for transporting molecular cargo, such as vesicles that might contain proteins or lipids or other macro molecules on its responsible for transporting this molecular cargo along the thin acting micro filaments. But the Miocene protein, as we'll see later in our course, is also involved in muscle contractions. And so later, when we talk mawr details about muscle contractions, we are going to see this Meyssan motor protein again. And so notice down below. On the left hand side, we're showing you a single Miocene molecule and noticed that at the tips here we have these pinkish structures that are referred to as the Miocene heads. And then this rest of the chain right here is referred to as the Mayas and tails. And so it's important to note is that many miles and molecules can actually aggregate together to form thick filaments. And so what you can see here this era represents protein aggregation, where we can take multiple mice and molecules and organize them in this fashion right here to create the thick mice and film it. And so this entire structure that we see here is referred to as thick mice and film it. And again we are going to see thick mice and film it again later in our course when we talk about muscle contraction. So be sure to remember the structure of the mice and motor protein. And so this concludes our introduction to the mice and motor protein and and our next lesson video will be able to talk about Kennison, so I'll see you guys in that video.

in this video, we're going to talk about the motor protein Kennison, which interacts with micro tubules. And so it's important to know that micro tubules sub units will actually assembled to make a polarized molecule with opposite Lee charged ends. And so if we take a look down below at our image, this micro tubules right here that we see is a polarized molecule with opposite Lee charged ends. You can see that on the left hand side, it has the negatively charged end. And on the right hand side, it has a positively charged end. And so Kennison is going to be a motor protein that specifically moves towards the positively charged end of the micro tubules so it can transport and pull molecular cargo such as vesicles or chromosomes along the micro tubules pulling the micro tubules cargo, the molecular cargo towards the positively charged end of the micro tubules. Now as well see down below. In our image, the Kennison heads are going to bind to the micro tube you'll whereas its light chains are gonna bind to the molecular cargo and so down below in our image, you can see that this is the Kennison motor protein and notice that three kidneys in hands which air down below here are attached directly to the micro tubules, as we mentioned up above and notice that the light chains which are pretty much right here the Keynesian light chains are attached to the molecular cargo, which is this vesicles up here. And so the Nissan Motor Protein is capable of pulling the vesicles or the molecular cargo towards the positively charged end of the micro tubules. So you can see that this arrow here represents the direction of movement towards the positively charged and and also noticed that the motor protein utilizes energy in the form of ATP in order to transport the molecular cargo. Now, if you haven't YouTube Kennison, then it's definitely something that you want to do because it's remarkable to see these depictions of the Kennison heads walking along the micro tubules. So for sure, if you've never googled Kennison or YouTube Kennison, make sure to YouTube Kennison so that you could get a better understanding of its movement along the micro tubules. Now, one thing that helps me memorize the direction of Keynesians movement, which is towards the positively charged end of the micro tubules is to note that, uh, Ken, which is found in the word Kinison eyes. Ah, word that means family and so up above You can see that there's this nice looking family here that are all happy, and that is just something very positive. And so Ken, which is family, is very positive. And that reminds me that Kennison moves towards the positively charged end of the micro to viel. And so this concludes our lesson on keynesians, uh, movement towards the positively charged and of the micro to Bill. And in our next lesson, video will be able to talk about, uh, dining and its interactions with the micro tubules. So I'll see you guys in that video.

in this video, we're going to talk about the motor protein dining, which also interacts with the micro tubules. And really, dining is the opposite of the motor protein Kennison. And that's because dining is a motor protein that specifically moves towards the negatively charged end of the micro tubules. And so that's going to allow it to transport and pull molecular cargo such as vesicles along the micro tubules. But this time towards the negatively charged and of the micro tubules, which is the opposite direction of Kinison. And so dining is actually responsible for the motion of Eukaryotic Flow, Gela and Celia and so down below. In our example here, you can see that we've got our micro tubules, which is a polarized molecule with a negatively charged in and a positively charged in, and notice that our motor protein dining here is actually moving in the opposite direction towards the negatively charged and over here. And so it also utilizes energy in the form of a teepee to move the vesicles, the molecular cargo again towards the negatively charged and and so one thing that helps me remember that dining moves towards the negatively charged end of the micro tubules is that dining kind of sounds like dying, and so dying is death, and death is not a good thing. So it's a negative thing. And so noticing that dining sounds like dying reminds me that dining moves towards the negatively charged end of the micro tubules. And so this year concludes our lesson on how dining moves towards the negatively charged end of the micro tubules, and we'll be able to get some practice utilizing the concepts that we've learned as we move forward in our course, So I'll see you guys in our next video.