Biochemistry

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10. Lipids

Integral Membrane Proteins

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concept

Integral Membrane Proteins

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Problem

Which of the amino acids of an integral membrane protein is most likely to be found contacting the membrane? 

a) Gly.

b) Gln.

c) Glu.

d) Ala.

e) Asp.

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Integral Membrane Proteins

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Problem

Which of the following statements about integral proteins is NOT correct? 

a) They are firmly associated with the membrane. 

b) They contain hydrophobic regions that interact with hydrophobic lipid tails. 

c) They can be easily extracted/separated from lipid membranes by just a relatively small change in the pH. 

d) They commonly contain α-helices or multi-stranded β-barrels.

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Problem

Integral membrane proteins are proteins that: 

a) Loosely associate with the membrane. 

b) Can be released from the membrane by slightly changing the pH. 

c) Can be released from the membrane by slightly changing the ionic strength of the solution. 

d) Penetrate or span the membrane.

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Problem

In the hydrophobic environment of a membrane, the α-helix of a protein folds such that the outer surfaces contain mostly _________________ amino acids, while _________________ amino acids are mostly buried on the inside. 

a) Non-polar; Hydrophobic. 

b) Polar; Hydrophilic. 

c) Hydrophobic; Non-polar. 

d) Polar; Hydrophobic. 

e) Non-polar; Hydrophilic.