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Biochemistry
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8. Protein Function
Fetal Hemoglobin
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concept
Fetal Hemoglobin
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2
Problem
Fetal hemoglobin binds oxygen with a ___________ affinity than adult hemoglobin, because it lacks the binding site for ______, which is an allosteric ____________ of oxygen binding to adult hemoglobin.
A
Lower ; BPG ; inhibitor.
B
Higher ; H+ ; inhibitor.
C
Higher ; BPG ; activator.
D
Higher ; BPG ; inhibitor.
E
Lower ; CO ; inhibitor.
3
Problem
Why is the decreased affinity of fetal hemoglobin for BPG advantageous?
A
With more BPG molecules bound, there are less heme groups available for O2 binding.
B
Decreased BPG binding biases FHb toward the R state.
C
More free BPG is available to bind adult hemoglobin, resulting in its shift to the R state.
D
BPG is available to bind to fetal myoglobin, helping to release O2 in fetal muscle tissue.