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Biochemistry
Learn the toughest concepts covered in Biochemistry with step-by-step video tutorials and practice problems by world-class tutors
7. Enzyme Inhibition and Regulation
Ubiquitination
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1
concept
Ubiquitination
5m
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2
concept
Ubiquitination
3m
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3
Problem
_________ involves covalent attachment of peptides leading to _________ of the target protein by ________.
A
Ubiquitination ; Activation ; Proteasome.
B
Glycosylation ; Degradation ; Ribosome.
C
Ubiquitination ; Degradation ; Proteome.
D
Ubiquitination ; Degradation ; Proteasome.
E
Acetylation ; Activation ; Proteasome.
4
Problem
Which of the following is true regarding protein ubiquitination?
A
Ubiquitin tagged proteins are usually degraded in the cell.
B
Ubiquitin is a ubiquitous, small nucleotide.
C
Covalent attachment of ubiquitin usually occurs via the R groups of methionine amino acid residues.
D
Ubiquitin links to the target protein only via hydrogen bonds.
E
Only a and c are true.
F
All of the above are true.
G
None of the above are true.
5
Problem
Ligation of a ubiquitin peptide’s ______________ charged carboxylate group to the R-group of a target protein’s ___________ residue forms a(n) _____________ bond.
A
Neutrally ; Histidine ; Hydrogen.
B
Negatively ; Leucine ; Isopeptide.
C
Positively ; Lysine ; Ionic.
D
Positively ; Lysine ; Disulfide.
E
Negatively; Lysine ; Hydrogen.
F
Negatively ; Lysine ; Isopeptide.