Multiple Choice
Given the amino acid sequence DAHGHFLKAGMT, what reagent would cleave the last residue, T, from the peptide? That is, one of the products after treatment will be the free amino acid: T.
5. Protein Techniques
Chemical Cleavage of Bonds
Struggling with Biochemistry?
Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
Which of the following statements about cystine is correct?
A
Cystine is formed through a peptide linkage between two cysteines.
B
Cystine forms when the -CH2-SH group is oxidized to form a -CH2-S-S-CH2- disulfide bridge between 2 cysteines.
C
Cystine is formed by the oxidation of the carboxylic acid groups on two cysteines.
D
Two cystines are released when a -CH2-S-S-CH2- disulfide bridge is reduced to -CH2-SH.
Verified step by step guidance1
Understand the structure of cysteine: Cysteine is an amino acid with a thiol group (-SH) attached to its side chain.
Recognize the process of oxidation: In biochemistry, oxidation often involves the loss of electrons or the formation of disulfide bonds.
Identify the formation of cystine: Cystine is formed when two cysteine molecules undergo oxidation, resulting in the formation of a disulfide bond (-S-S-) between their thiol groups.
Clarify the disulfide bridge: The disulfide bridge in cystine is represented as -CH2-S-S-CH2-, linking two cysteine residues.
Understand reduction of disulfide bonds: When a disulfide bridge is reduced, it breaks into two thiol groups (-SH), regenerating the original cysteine molecules.
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