Put the number of the type of immune system hypersensitivity in the blank next to each manifestation. Each of the four types may be used more than once or not at all. If the manifestation is not an immune hypersensitivity, put zero in the blank.


1. Acute anaphylaxis
2. Allergic contact dermatitis
3. Systemic lupus erythematosus
4. Allograft rejection
5. AIDS
6. Graft-versus-host disease
7. Milk allergy
8. Rheumatoid arthritis (RA)
9. Asthma
10. Hay fever


I. Type I hypersensitivity
II. Type II hypersensitivity
III. Type III hypersensitivity
IV. Type IV hypersensitivity
0. Not a hypersensitivity

Verified step by step guidance

1. Identify the characteristics of each type of hypersensitivity: Type I involves IgE-mediated reactions, Type II involves antibody-mediated cytotoxic reactions, Type III involves immune complex-mediated reactions, and Type IV involves T-cell mediated reactions.
2. Match each manifestation with the appropriate type of hypersensitivity based on its characteristics. For example, acute anaphylaxis is typically a Type I hypersensitivity reaction.
3. Consider manifestations that involve immune complexes, such as systemic lupus erythematosus, which is associated with Type III hypersensitivity.
4. For conditions involving T-cell mediated responses, such as allergic contact dermatitis, identify them as Type IV hypersensitivity.
5. For manifestations that do not fit any hypersensitivity type, such as AIDS, classify them as 0, indicating they are not hypersensitivity reactions.

Key Concepts

Types of Hypersensitivity

Hypersensitivity reactions are classified into four types based on the immune mechanism involved. Type I hypersensitivity is mediated by IgE antibodies and involves immediate allergic reactions, while Type II involves IgG or IgM antibodies against cell surface antigens. Type III is characterized by immune complex formation, and Type IV is a delayed-type reaction mediated by T cells. Understanding these types is crucial for identifying the correct hypersensitivity associated with various clinical manifestations.

Immune System Disorders

Immune system disorders can manifest as hypersensitivity reactions, autoimmune diseases, or immunodeficiencies. Conditions like systemic lupus erythematosus and rheumatoid arthritis are autoimmune disorders where the immune system mistakenly attacks the body's own tissues. In contrast, AIDS represents an immunodeficiency where the immune system is compromised, making it essential to differentiate between these conditions when categorizing manifestations.

Clinical Manifestations of Hypersensitivity

Each type of hypersensitivity is associated with specific clinical manifestations. For example, Type I hypersensitivity can lead to acute anaphylaxis and allergic reactions like hay fever and asthma, while Type IV hypersensitivity is linked to delayed reactions such as allergic contact dermatitis and graft-versus-host disease. Recognizing these associations helps in accurately assigning the correct type of hypersensitivity to each manifestation listed in the question.