POCl3 Dehydration Practice Problems
Alcohols can undergo dehydration when they are mixed with phosphorus oxychloride (POCl3) in pyridine. In the reaction between an alcohol and phosphorus oxychloride, the alcohol displaces a chloride ion from phosphorus to give an alkyl dichlorophosphate ester. The dichlorophosphate ester then reacts with pyridine base to give an E2 elimination.
Suggest a mechanism for the dehydration of cyclopentanol by POCl3 in pyridine.