Organic Chemistry
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Suggest a reagent for the formation of the alcohol in the following reaction.
Perkin condensation is quite similar to the aldol and Claisen condensations. Draw the structure of compounds formed when the product of the following Perkin condensation reaction is treated with water.
In contrast to the reaction (i), reaction (ii) predicts the formation of a thioether. Explain this phenomenon.
When (S)-3-chloro-1,1-dimethylcyclopentane reacts with sodium cyanide, a single product is formed. Explain why, upon the reaction of the same molecule with water, a mixture of two enantiomers is formed.
Contrary to expectation, upon the addition of the 4th Cl to methane, the boiling point suddenly becomes very low. Provide an explanation as to why this is the case.
Arrange the following ions according to increasing nucleophilic strength using their conjugate acids' pKa values.
Provide the reagent to complete the conversion of the alkyl halide to an alcohol.
Draw the major product(s) of the reaction shown below.
Identify the major product(s) of the reaction shown below.
An intramolecular substitution reaction occurs when (1R,2R)-2-chlorocyclohexan-1-ol is treated with a base like NaOH to produce a cyclic ether. However, when (1S,2R)-2-chlorocyclohexan-1-ol is reacted under the same conditions, a diol forms instead. Explain.
Which reactions would occur faster than the remaining one if the nucleophile concentration was increased?
Acetone can be used as a solvent in the reaction between an alkyl bromide and potassium iodide to increase the amount of alkyl iodide formed. Explain. (Hint: Potassium iodide is soluble in acetone but potassium bromide is not.)
Briefly explain why the alkyl halide shown reacts much more rapidly with guanine than a primary alkyl halide like 1-bromobutane.