Organic Chemistry
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True or False. The HB+ in the mechanism for the acid-catalyzed hydrolysis of esters is most likely to be H3O+.
Draw a mechanism for the acid-catalyzed reaction of propionic acid and ethanol to form ethyl propionate, including all curved arrows. As a guide, consider the mechanism for the acid-catalyzed hydrolysis of an ester, where HB+ and :B represent the species that donate and remove protons, respectively.
Determine the acid-catalyzed hydrolysis products of the ester given below.
Consider the following derivative of the known sweetener, aspartame.
What are the products obtained when it undergoes complete hydrolysis in a dilute solution of HCl?
Predict the product(s) for the following reaction and propose a mechanism.
Propose the reagents required for the following conversion.butan-1-ol → 2-hydroxypentanoic acid
Consider the following compound that has been labeled with the O-18 isotope of oxygen.
Write a plausible mechanism for the hydrolysis of this compound under acidic conditions.
Suggest a suitable mechanism to show the base-catalyzed hydrolysis of 2-phenylacetonitrile into 2-phenylacetate and ammonia.
The general reaction below is the Reformatsky reaction wherein an organozinc reagent is used to add to the carbonyl group of an aldehyde or ketone. However, nucleophilic addition does not occur for an ester group because the organozinc is less reactive than a Grignard reagent. To prepare the organozinc reagent, an α-bromo ester is treated with zinc.
Using the Reformatsky reaction, show the following compound can be synthesized.