Organic Chemistry
When a substituent moves from the equatorial to the axial position in a chair-chair interconversion, its A value on a cyclohexane ring corresponds to its ∆G° value. A values are always positive numbers because most substituents prefer to be in the equatorial position. Calculate ∆G° and Keq for the chair-chair interconversions shown using the given A values.
(i) Calculate the steric strain in each of the chair conformers of 1,1,4-trimethylcyclohexane if a CH3−H and a CH3−CH3 1,3-diaxial interactions are 0.87 and 3.7 kcal/mol, respectively.(ii) Which conformer predominates at equilibrium?
