Cope Elimination Practice Problems

Determine the compound(s) produced from the reaction of the given tertiary amine with hydrogen peroxide and heat.

What is the compound(s) produced for the reaction of the given tertiary amine with hydrogen peroxide and heat?

Draw the structures of the major products expected from the reactions given below.

Show how the following syntheses can be accomplished.

Provide the expected final products when N,N-dimethylcyclopentanamine is treated with hydrogen peroxide and heated.

Give the expected major products when N,N-diethylcyclopentanamine is treated with hydrogen peroxide and heated. 

Draw the expected final products when N,N-dimethylpropan-2-amine is treated with hydrogen peroxide and heated.

What are the expected major products when N-ethylpyrrolidine is treated with hydrogen peroxide and heated? 

Draw the expected products from the reaction of the following tertiary amines with H₂O₂ followed by heat.

Provide the missing reagent for the reaction shown below:

What will be the product obtained when N-isopropylpentan-3-amine is reacted with sodium nitrite in dilute hydrochloric acid?

Determine the product obtained from the reaction given below:

When the following (R,R) isomer of an amine undergoes either Hofmann or Cope elimination reaction, the major product formed is the less substituted alkene (Hofmann). However, some Zaitsev products may also form. An alkene with an (E) configuration is formed from the Hofmann elimination, while an alkene with a (Z) configuration is formed from the Cope elimination reaction. Draw the transition states of both reactions to illustrate the formation of the Zaitsev products.

During an unfortunate mishap, water entered a large container filled with ethyl isocyanate. A significant amount of ethyl isocyanate was released through the pressure-relief valves and the vapors spread into nearby areas causing harm to many people.

(1) Write an equation for the reaction that occurred inside the tank.

(2) Propose a possible mechanism for this reaction.