Malonic Ester Synthesis - Online Tutor, Practice Problems & Exam Prep

Create a synthesis for the molecule shown below starting from the given compound.

Butalbital is a sedative that reduces anxiety while also causing sleepiness and relaxation. Provide the synthetic pathway for the production of Butalbital using diethyl malonate and urea as starting materials.

What carboxylic acid is formed in the following malonic ester synthesis?

Explain why the malonic ester synthesis can not be used to produce the following carboxylic acid.

Draw the structure of carboxylic acid formed in the following reaction.

Provide suitable reactions to produce the following compounds using malonic ester synthesis.

Show how malonic ester synthesis can be used to produce the compounds given below.

What amino acid is obtained when 2-bromobutane is used in the third step of the N-phthalimidomalonic ester synthesis?

Provide the final products after the hydrolysis and decarboxylation of the compound shown below.

Illustrate how to produce the following using the malonic ester synthesis:

i) 5-phenylpentanoic acid

ii) cyclobutanecarboxylic acid

Provide the alkyl iodides used in the malonic ester synthesis to yield the carboxylic acids below.

a. butanoic acid

b. 2-ethylbutanoic acid