13. Alcohols and Carbonyl Compounds
Grignard Reaction
13. Alcohols and Carbonyl Compounds Grignard Reaction
22PRACTICE PROBLEM
The Reformatsky reaction can be used for the nucleophilic addition to the carbonyl of a ketone or an aldehyde. The reaction uses an organozinc reagent instead of a Grignard reagent. This organozinc reagent can be produced by the treatment of an α-bromo ester with zinc. The organozinc reagent is less reactive than a Grignard reagent therefore it can not be used for the nucleophilic addition to an ester.
Show how the given compound can be produced using a Reformatsky reaction.
The Reformatsky reaction can be used for the nucleophilic addition to the carbonyl of a ketone or an aldehyde. The reaction uses an organozinc reagent instead of a Grignard reagent. This organozinc reagent can be produced by the treatment of an α-bromo ester with zinc. The organozinc reagent is less reactive than a Grignard reagent therefore it can not be used for the nucleophilic addition to an ester.
Show how the given compound can be produced using a Reformatsky reaction.