5. Chirality
Calculations with Enantiomeric Percentages
5. Chirality Calculations with Enantiomeric Percentages
2PRACTICE PROBLEM
Thalidomide is a drug used to treat cancer, several skin disorders, and particular complications caused by human immunodeficiency virus (HIV). The (–)-isomer is the biologically active form of thalidomide. A sample of a mixture of thalidomide has a specific rotation of [α]D = –45.1°. Using the specific rotation of the pure enantiomer below, determine the ratio of (+)- to (–)-thalidomide in the sample.
Thalidomide is a drug used to treat cancer, several skin disorders, and particular complications caused by human immunodeficiency virus (HIV). The (–)-isomer is the biologically active form of thalidomide. A sample of a mixture of thalidomide has a specific rotation of [α]D = –45.1°. Using the specific rotation of the pure enantiomer below, determine the ratio of (+)- to (–)-thalidomide in the sample.