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13. Mendelian Genetics

Autosomal Inheritance

13. Mendelian Genetics

Autosomal Inheritance

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Autosomal Inheritance

Autosomal Inheritance

Jason Amores Sumpter

Autosomal Disorders

Autosomal Disorders

Jason Amores Sumpter

Practice this topic

Multiple Choice

If a genetic counselor was examining a pedigree chart and noticed an occurrence of a disease in every generation, the counselor would most likely assume that the disease was caused by:

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Multiple Choice

The pedigree chart shown depicts the inheritance pattern of __________.

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Multiple Choice

Determine the likely pattern of inheritance in the following pedigree. List the genotypes of the numbered individuals in this order: #1, #2, and #3.

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The following pedigree is for the ABO blood type group, which is an example of autosomal inheritance. Using the I^A, I^B, i for the alleles, fill in the top half of each box/circle with the genotype. Also, fill in the bottom half of each box/circle with the phenotype (A, B, AB, or O blood type). If it is impossible to know for certain a specific allele in the genotype, then place a '?' as a placeholder to represent the allele that is in question.

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Multiple Choice

The genetic disease cystic fibrosis is caused by a defective allele that __________.

Multiple Choice

Tom's brother suffers from phenylketonuria (PKU), a recessive disorder. Tom and the brother's parents do not have PKU. What are the chances that Tom is a carrier of the recessive PKU allele?

Multiple Choice

A couple, both descended from eastern European (Ashkenazic) Jews, visit a genetic counselor before trying to have children. In view of their ethnic background, the counselor recommends that they be tested to see if they are carriers for __________.

Multiple Choice

Cystic fibrosis, which is usually lethal before the age of reproduction, is a homozygous recessive trait. Why do cases continue to arise, even though people with the disease rarely live to reproduce?

Multiple Choice

What kind of protection does the Genetic Information Nondiscrimination Act of 2008 provide the public with regard to the use of genetic information?

Multiple Choice

In which genetic testing procedure would a physician remove a small tissue sample from a membrane of fetal genetic origin?

Multiple Choice

Fetal cells may be removed along with fluid from the womb by a process known as __________.

Multiple Choice

When two average-height parents give birth to a child exhibiting achondroplasia, it is most likely due to a new mutation. This is because __________.

Multiple Choice

Huntington's disease is an example of a genetic disorder caused by __________.

Multiple Choice

It is far more common to find human genetic disease caused by __________ alleles than by __________ alleles because __________.

Textbook Question

Hemochromatosis is an inherited disease caused by a recessive allele. If a woman and her husband, who are both carriers, have three children, what is the probability of each of the following? a. All three children are of normal phenotype. b. One or more of the three children have the disease. c. All three children have the disease. d. At least one child is phenotypically normal.

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Textbook Question

Among heritable diseases, which genotype can be present in an individual without causing a disease phenotype in that individual? a. heterozygous for a dominant disease; b. homozygous for a dominant disease; c. heterozygous for recessive disease; d. homozygous for a recessive disease e. all of the above

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Textbook Question

Karen and Steve each have a sibling with sickle-cell disease. Neither Karen nor Steve nor any of their parents have the disease, and none of them have been tested to see if they carry the sickle-cell allele. Based on this incomplete information, calculate the probability that if this couple has a child, the child will have sickle-cell disease.

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Textbook Question

The pedigree below traces the inheritance of alkaptonuria, a biochemical disorder. Affected individuals, indicated here by the colored circles and squares, are unable to metabolize a substance called alkapton, which colors the urine and stains body tissues. Does alkaptonuria appear to be caused by a dominant allele or by a recessive allele? Fill in the genotypes of the individuals whose genotypes can be deduced. What genotypes are possible for each of the other individuals?

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Textbook Question

Imagine that you are a genetic counselor, and a couple planning to start a family comes to you for information. Charles was married once before, and he and his first wife had a child with cystic fibrosis. The brother of his current wife, Elaine, died of cystic fibrosis. What is the probability that Charles and Elaine will have a baby with cystic fibrosis? (Neither Charles, Elaine, nor their parents have cystic fibrosis.)

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Textbook Question

You have crossed two Drosophila melanogaster individuals that have long wings and red eyes—the wild-type phenotype. In the progeny, curved wings and lozenge eyes mutant phenotypes appear as follows According to these data, is the curved-wing allele autosomal recessive, autosomal dominant, sex-linked recessive, or sex-linked dominant?

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Textbook Question

You have crossed two Drosophila melanogaster individuals that have long wings and red eyes—the wild-type phenotype. In the progeny, curved wings and lozenge eyes mutant phenotypes appear as follows Is the lozenge-eyed allele autosomal recessive, autosomal dominant, sex-linked recessive, or sex-linked dominant?

Has a video solution.

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