Organic Chemistry

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12. Alcohols, Ethers, Epoxides and Thiols

Alcohol Protecting Groups

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Alcohols are highly reactive. This can be a problem if we want to react on some other part of the molecule. How can we guarantee that a reaction won’t take place at the alcohol? 

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General features of Alcohol Protecting Groups.

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For example, the following substitution reaction has a major problem as drawn. Can you spot the issue?

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Protecting groups are reversible reactions that temporarily block groups from reacting, so that we can transform other parts of the molecule.