The Michael Reaction is a 1,4-conjugate addition of an enone with an enolate and always forms 1,5-dicarbonyls.
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concept
General Reaction
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Hey, guys. So in this video, we're gonna focus on a specific form of conjugal edition toe A N own called the Michael Reaction. Okay, so the Michael Reaction Guys is a 14 congregate addition. Remember that when I say 14 congregate edition, I'm talking about an n o. Okay, I'm talking about adding right there. Okay? Often e known with an equally Remember that if specifically, if your nuclear file is an easily that is called a michael reaction. Okay, if that is your if you're if that is your nuclear file, okay? So, basically, if you think about it, this is kind of like an algal times to write, because your first Aldo reaction created the unknown, and now I'm doing a second outdoor reaction. Okay, so I like to think of a my correction as an adult times to. Okay, now, what's cool about these is that they're always gonna form the same thing. They're always gonna form 15 die Carmen eels. So let me show you guys how to draw the products first, and then I'll show you the whole mechanism. Okay, So the products are really easy in this situation because you're doing a concrete edition. My rules of where tow line up your italy in your electric file for all dog go out the window. I don't want that anymore. What I prefer you do is to draw the unknown at the bottom exactly the way it is, but without its double bond, and then draw a single bond coming off of the conjugate position. So position for shoot. I'm trying to get a new color position for and then just draw that attached to your family. Okay? That's how you draw the product. It's literally in on Emily New Bond. And then obviously I pointed this out earlier. No, pi bond. Okay, so don't draw a double bond there. Okay? So what I like to do is, regardless of whatever the nuclear foul is, I like to just draw it right on top. Okay, But we have to go into the mechanism. So in this next video, I'm gonna show you the full mechanism for the Michael reaction. And this is also gonna help you guys understand why that pie bond isn't there. Because that could be a little confusing. Why is that pi bon gone? We're gonna talk about it. So that's coming up in the next video
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concept
General Mechanism
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Alright, guys, let's bring the molecule down and we're gonna draw the full mechanism groups make sure got right. Cool. Okay, so I got this molecule and I've got my Eataly. Okay. So, guys, what's gonna happen is that remember that I said I have to Elektra Filic regions. I have this electric fall here. We're used to seeing that, but this is also an electrical. Now, it doesn't look like it because it's a double bond, but it is because it can resonate. That positive charge can resonate. So in my first step, I actually get this kind of strange arrow off the negative attacking this carbon. Okay, now, if I make that bond I have to break upon. So I'm gonna break this bond and make adult one here. I'm gonna break this bond and make a lone pair there. So what I'm gonna get is something. Looks like this O negative. Double bond, single bond. That single bond has a new bond that's attached to my old anyway. Okay, So is that making sense? So far? I have a negative charge, and I have a double bond. Okay, now what's gonna happen is that this molecule gets protein ated because notice that we haven't in late. Right? So there must be some kind of confident that took off that h. So let's just say that it had been hydroxide, so we'll use water to protein eight. Okay, so now we're gonna protein eight. Wow, it's terrible arrow. We're gonna protein eat. And that's going to give us a molecule that you should know something about. Let's draw it first. Alright, guys. So I have a molecule. It's similar to my 15 die Carbonell. But what do we call this species down here? What is that, guys? Do you recognize that that's a vinyl alcohol? Or more specifically, this is an eternal taught him, er right. That's an Enel Tanamor. Right? So now this is in a basic environment. So through taught memorization that double bond that anal Tanamor is going to switch to the Keto form, remember that the Keto form is pretty much always the most stable. Unless it's a beta die Carbonell. So through totalization, I'm going to regenerate the Keto form and I'm gonna get this. Okay? If you want more information on the top memorization mechanism, definitely feel free toe go through the top immunization videos that I have, and I'll explain every explain everything there. But at this point of the course, you just need to able to use Todd Memorization. You don't have to draw every time. Okay, guys. So that shows you guys the full mechanism for Michael reaction, which this also applies to any conjugal edition. Guys, just you know this mechanism, this is the same mechanism for any conjugate edition. Okay, so now you know what that looks like. And we know how to make a 15 die carbon deal. So let's move on to the next video.
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Problem
Determine the product in the following conjugated addition reaction.
A
B
C
D
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Problem
Determine the product in the following conjugated addition reaction.
A
B
C
D
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Problem
Determine the product in the following conjugated addition reaction