Organic Chemistry

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18. Reactions of Aromatics:EAS and Beyond

Acylation of Aniline

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Since aniline is strongly activated, unwanted reactions can occur. However, we're in luck because we can avoid this issue. Let's see how. 

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concept

Protection of Aniline Derivatives

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To avoid this, we can reversibly acetylate (protect) the amino group to make it moderately activating.

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example

Synthesize the target molecule

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