Organic Chemistry

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12. Alcohols, Ethers, Epoxides and Thiols

Williamson Ether Synthesis

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There are 4 major methods to create ethers. Most of these should look familiar in some way since they are variations of reactions we have used before. 

Williamson Ether Synthesis

The name given for the SN2 substitution of an oxide with an alkyl halide.

  • Only works with 0°, 1° alkyl halides since 2° and 3° alkyl halides will favor E2
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The Mechanism of Williamson Ether Synthesis.

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