Organic Chemistry

Learn the toughest concepts covered in Organic Chemistry with step-by-step video tutorials and practice problems by world-class tutors.

22. Condensation Chemistry

Robinson Annulation

1,5-dicarbonyl compounds generated from the Michael Reaction (enone + enolate) have the ability to undergo intramolecular self-condensation into 6-membered enones. Are you impressed yet?

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concept

Robinson Annulation

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example

Predict the Major Product

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Problem

Provide the product for the following Robinson Annulation Reaction.

If you noticed a methyl group that vanished around 3:50 in the above video, you are not alone! Place a methyl there in your final answer and you will be good:)

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Problem

How would you prepare the following compound using a Robinson annulation reaction between a di-ketone and an alpha, beta unsaturated ketone? 

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Problem

How would you prepare the following compound using a Robinson annulation reaction between a ketone and an alpha, beta unsaturated ketone? 

Great job, guys! You survived.