12. Alcohols, Ethers, Epoxides and Thiols
Thiol Reactions
Problem 21.73
Textbook Question
Textbook Question(•••) FROM THE LITERATURE The following covalent inhibitor blocks function in a protease found in the porcine epidemic diarrhea virus by reacting with a cysteine amino acid residue (shown below) in the active site. Draw the expected complex that forms between the inhibitor and the enzyme active site (J. Med. Chem. 2017, 60, 3212–3216.) [Assume the presence of active site bases if you need them.]
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