Multiple Choice
The use of an airborne infection isolation room (AIIR) falls under which level of the hierarchy of controls for infection prevention?
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1. Introduction to Microbiology
Introduction to Microbiology
Multiple Choice
Why does Staphylococcus aureus use Protein A to bind IgG antibodies?
A
To prevent opsonization and phagocytosis by immune cells
B
To increase antibody-mediated neutralization of toxins
C
To enhance complement activation and promote inflammation
D
To facilitate direct lysis of host cells
Verified step by step guidance1
Understand the role of Protein A in Staphylococcus aureus: Protein A is a surface protein that binds to the Fc region of IgG antibodies.
Recall the structure of an antibody: IgG antibodies have two main regions - the Fab region that binds antigens, and the Fc region that interacts with immune cells.
Recognize that by binding the Fc region of IgG, Protein A disrupts the normal orientation of antibodies on the bacterial surface, preventing immune cells from recognizing and binding to the bacteria effectively.
This interference inhibits opsonization, a process where antibodies mark pathogens for phagocytosis by immune cells such as macrophages and neutrophils.
Therefore, Protein A helps Staphylococcus aureus evade the immune system by preventing opsonization and subsequent phagocytosis, enhancing bacterial survival.
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