Which markers are found on all nucleated cells?

• A. MHC class I.
• B. MHC class II.
• C. CD4.
• D. CD8.

Answer: (A)

Verified step by step guidance

1. Understand the concept of 'nucleated cells': These are cells that contain a nucleus, which includes most cells in the body except for mature red blood cells.
2. Learn about Major Histocompatibility Complex (MHC) molecules: MHC class I molecules are present on all nucleated cells and play a crucial role in the immune system by presenting peptide fragments to T cells.
3. Differentiate between MHC class I and MHC class II: MHC class I is found on all nucleated cells, while MHC class II is typically found on antigen-presenting cells such as macrophages, dendritic cells, and B cells.
4. Explore the roles of CD4 and CD8 markers: CD4 is a marker found on helper T cells, while CD8 is found on cytotoxic T cells. These markers are not present on all nucleated cells but are specific to certain types of immune cells.
5. Conclude that MHC class I is the marker found on all nucleated cells, as it is universally expressed across these cell types, unlike MHC class II, CD4, and CD8 which have more restricted expression patterns.