Which of the following is NOT a major organ that can be a target of immune complex deposition?

• A. Kidneys
• B. Joints
• C. Skin
• D. Liver

Answer: (D)

Verified step by step guidance

1. Understand that immune complex deposition occurs when antigen-antibody complexes accumulate in tissues, triggering inflammation and damage.
2. Identify the major organs commonly affected by immune complex deposition, which typically include the kidneys, joints, and skin due to their vascular and tissue characteristics.
3. Recall that the kidneys are a primary target because immune complexes can deposit in the glomeruli, leading to conditions like glomerulonephritis.
4. Recognize that joints are commonly involved, as immune complexes can cause inflammation resulting in arthritis.
5. Note that the liver is generally not considered a major target for immune complex deposition compared to the kidneys, joints, and skin, making it the correct answer to the question.