Which of the following reactions is most likely to cause a frameshift mutation in an organic molecule?

• A. Insertion or deletion of nucleotides
• B. Oxidation
• C. Deamination
• D. Alkylation

Answer: (A)

Verified step by step guidance

1. Understand the concept of a frameshift mutation: A frameshift mutation occurs when nucleotides are inserted or deleted from a DNA sequence, causing a shift in the reading frame of the genetic code.
2. Identify the types of mutations: In the context of DNA, common mutations include insertions, deletions, substitutions, and chemical modifications like oxidation, deamination, and alkylation.
3. Analyze the options: Consider how each option affects the DNA sequence. Insertion or deletion of nucleotides directly alters the number of nucleotides, potentially causing a frameshift.
4. Evaluate the other options: Oxidation, deamination, and alkylation typically result in point mutations or chemical modifications, which do not usually cause frameshift mutations.
5. Conclude which reaction is most likely to cause a frameshift mutation: Based on the analysis, insertion or deletion of nucleotides is the most likely to cause a frameshift mutation.